Congenital pachyonychia

Chidule cha Pachyonychia Congenita

Pachyonychia congenita (PC) ndi matenda osowa kwambiri omwe amakhudza khungu ndi misomali. Zizindikiro nthawi zambiri zimawonekera pa kubadwa kapena kuyambika kwa moyo, ndipo matendawa amakhudza anthu amitundu yonse ndi mafuko onse.

PC imayamba chifukwa cha masinthidwe omwe amakhudza ma keratin, mapuloteni omwe amapereka chithandizo chamagulu ku maselo, ndipo amagawidwa m'magulu asanu kutengera jini ya keratin yomwe ili ndi kusintha. Zizindikiro zimasiyana munthu ndi munthu ndipo zimadalira mtundu, koma makulidwe a misomali ndi ma calluses pamapazi amapezeka pafupifupi nthawi zonse. Chizindikiro chofooketsa kwambiri ndi ma calluses opweteka pazitsulo zomwe zimapangitsa kuyenda kukhala kovuta. Odwala ena amadalira ndodo, ndodo, kapena njinga ya olumala kuti athetse ululu poyenda.

Palibe mankhwala enieni a PC, koma pali njira zothetsera zizindikiro, kuphatikizapo ululu.

Ndani amapeza congenital pachyonychia?

Anthu omwe ali ndi congenital pachyonychia amakhala ndi masinthidwe mu umodzi mwa majini asanu a keratin. Ofufuza apeza kusintha kopitilira 115 mu majini okhudzana ndi matendawa. Nthawi zina, PCa imachokera kwa makolo, pamene ena alibe mbiri ya banja ndipo chifukwa chake ndi kusintha kwachisawawa. Matendawa ndi ochuluka mwachibadwa, kutanthauza kuti kopi imodzi ya jini yosinthika ndiyokwanira kuyambitsa matendawa. PC ndiyosowa kwambiri. Matendawa amakhudza anthu amitundu yonse komanso amitundu yonse.

Mitundu ya congenital pachyonychia

Pali mitundu isanu ya pachyonychia congenita ndipo amagawidwa kutengera jini yosinthidwa ya keratin. Misomali yolimba ndi ma calluses opweteka pamapazi amapezeka m'mitundu yonse ya matendawa, koma kupezeka kwa zinthu zina kungadalire kuti jini ya keratin imakhudzidwa bwanji ndipo mwina pakusintha kwake.

Zizindikiro za congenital pachyonychia

Zizindikiro ndi kuuma kwa PCa zimatha kusiyana kwambiri, ngakhale pakati pa anthu omwe ali ndi mtundu womwewo kapena m'banja lomwelo. Zizindikiro zambiri zimawonekera m'miyezi kapena zaka zoyambirira za moyo.

Ma PC odziwika kwambiri ndi awa:

• Zowawa ma calluses ndi matuza pa phazi la mapazi. Nthawi zina, calluses itch. Ma calluses ndi matuza amathanso kupanga m'manja.
• Misomali yokhuthala. Si misomali yonse yomwe imakhudzidwa ndi wodwala aliyense wa PC, ndipo mwa anthu ena misomali siikhuthala. Koma odwala ambiri akhudza misomali.
• cysts mitundu yosiyanasiyana.
• Ma tubercles ozungulira tsitsi m'malo omwe amakangana, monga chiuno, chiuno, mawondo ndi zigongono. Amapezeka kwambiri mwa ana ndipo amachepetsa pambuyo pa unyamata.
• Chophimba choyera pa lilime ndi m'masaya amkati.

Zochepa kwambiri pa PC ndizo:

• Zilonda pa ngodya za pakamwa.
• Mano pobadwa kapena asanabadwe.
• Filimu yoyera pakhosi kutulutsa mawu achipongwe.
• Kupweteka kwambiri pakuluma koyamba ("first bite syndrome"). Ululu umakhala pafupi ndi nsagwada kapena makutu ndipo umatenga masekondi 15-25 pamene ukudya kapena kumeza. Matendawa amapezeka kwambiri mwa ana aang'ono ndipo angayambitse vuto la kuyamwitsa kwa ana ena. Nthawi zambiri amachoka paunyamata.

Zifukwa za congenital pachyonychia

Pachyonychia congenita imayamba chifukwa cha kusintha kwa majini omwe amalemba ma keratini, mapuloteni omwe ndi zigawo zikuluzikulu za khungu, misomali, ndi tsitsi. Kusintha kwa masinthidwe kumalepheretsa keratini kupanga maukonde amphamvu a ulusi omwe nthawi zambiri amapatsa mphamvu ma cell a khungu. Chotsatira chake, ngakhale ntchito wamba monga kuyenda zingayambitse kuwonongeka kwa maselo, potsirizira pake kumabweretsa matuza opweteka ndi ma calluses, omwe ndi zizindikiro zofooketsa kwambiri za matendawa.